St. John's College is housed in a building adjacent to the St. John's Hospital at 729 East Carpenter Street in Springfield, Illinois. The administrative offices, financial office, faculty offices and classrooms are all conveniently located in this two-story building. A fully equipped nursing arts laboratory with state-of-the-art material is provided for student use in the Simulation Center located at 850 East Madison Street, Springfield, Illinois. Students have access to the college's computer laboratory. Instructional aids available include Microsoft Office 2010 package with Word, Excel, Power Point, various software-learning programs and NCLEX Review programs.
The Financial Aid Office is located on the first floor of the college to allow ready access in the event questions or concerns arise about financial aid matters. A student lounge is located on the second floor available to students. Reasonably priced cafeteria services are readily available in the hospital. A large, well-provisioned Health Sciences Library is located on the second floor of St. John's Hospital. In addition to the educational opportunities offered on the St. John's campus, students may use the medical library at Southern Illinois School of Medicine and the many services available in the city of Springfield. Lincoln Library , the state library and the various governmental offices are within walking distance of the college.